![]() CDC continues to monitor all variants circulating within the United States. ![]() Vaccines approved and authorized for use in the United States are effective against the predominant variant circulating in the United States and effective therapeutics are available.To date, no variants of high consequence have been identified in the United States.The SIG Variant classification scheme defines four classes of SARS-CoV-2 variants:.Evidence suggesting that Delta does not currently pose a significant risk to public health in the United States.Significant and sustained reduction in its national and regional proportions over time.This new classification was based on the following: On Apthe U.S government SARS-CoV-2 Interagency Group (SIG) downgraded Delta from a Variant of Concern to a Variant Being Monitored.Available data for other variants with fewer substitutions in the spike protein that indicate reduced susceptibility to certain monoclonal antibody treatments.Available data for other variants with fewer substitutions in the spike protein that indicate a reduction in neutralization by sera from vaccinated or convalescent individuals.The number and locations of substitutions in the spike protein.Transmission and replacement of the Delta variant in South Africa.Detection of cases attributed to Omicron in multiple countries, including among those without travel history.This classification was based on the following: government SARS-CoV-2 Interagency Group (SIG) classified Omicron as a Variant of Concern (VOC). SARS-CoV-2 genetic lineages in the United States are routinely monitored through epidemiological investigations, virus genetic sequence-based surveillance, and laboratory studies.Genetic lineages of SARS-CoV-2 have been emerging and circulating around the world since the beginning of the COVID-19 pandemic.
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